Prof Dr. Zhonggao Gao | Design of Novel | Best Researcher Award

Prof Dr. Zhonggao Gao, Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Materia Medica, China

🌟 Prof Dr. Zhonggao Gao, affiliated with the Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Materia Medica, is a trailblazer in academic research and drug development. Renowned for pioneering Hepatocyte Growth Factor mRNA therapy using muscle cell-targeted lipopolymer nanoparticles, he tackles severe lower extremity ischemia. His innovation extends to cell membrane-coated metal-organic framework nanoparticles for combined photodynamic therapy and tumor metabolic reprogramming. Notably, his biomineralization-inspired dasatinib nanodrug showcases sequential infiltration for potent solid tumor treatment. Engaged in clinical transformation, his projects include paclitaxel nanomicell design and multifunctional antibacterial hydrogel pharmaceutical research. 🚀

🔍 Program and Experience: Academic Research

Dr. Zhonggao Gao is a distinguished researcher at the Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Materia Medica, China. His groundbreaking work spans various aspects of academic research, with a focus on innovative therapies and drug development.

Research Highlights:

Hepatocyte Growth Factor mRNA Therapy 🧬: Developed a revolutionary therapy using muscle cell-targeted lipopolymer nanoparticles for severe lower extremity ischemia. Cell Membrane-Coated Nanoparticles 🌌 : Spearheaded the creation of cell membrane-coated metal-organic framework nanoparticles for combination photodynamic therapy, coupled with tumor metabolic reprogramming. Biomineralization-Inspired Nanodrug 💊 : Innovated a dasatinib nanodrug with sequential infiltration, drawing inspiration from biomineralization, for highly effective solid tumor treatment.

Drug Development Project: Clinical Transformation

Paclitaxel Nanomicell 🎯: Led the design, production, and in vivo anti-tumor evaluation of paclitaxel nanomicell, contributing to advancements in drug delivery for cancer treatment. Multifunctional Antibacterial Hydrogel 🌐 : Conducted groundbreaking pharmaceutical research in designing multifunctional antibacterial hydrogel, addressing the critical need for versatile antibacterial solutions.

Professional Profiles:

Scopus Profile

The impact of her research is evident in citation metrics and indices from Google Scholar:

Cited by: All – 6,871.
Citations – 5,672.
h-index – 36.
Documents – 124.

A prolific researcher making meaningful contributions to the academic world!

Research Focus 🚀:

Prof Dr. Zhonggao Gao, a distinguished researcher at the Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Materia Medica in China, specializes in pioneering advancements in peptide‒drug conjugates. 🧬 His research spans a diverse range of impactful projects, from developing biomimetic multifunctional nanodrugs for regulating abnormal tumor metabolism to creating versatile flexible micelles for effective oral delivery of paclitaxel. 🌐 Dr. Gao’s groundbreaking work extends to the development of novel paclitaxel-loaded ZIF-8 metal-organic framework nanoparticles, modified with peptide dimers for inhibiting prostate cancer cells. Additionally, he has contributed significantly to the field with a triple cross-linked dynamic responsive hydrogel loaded with selenium nanoparticles, modulating the inflammatory microenvironment via PI3K/Akt/NF-κB and MAPK signaling pathways. ⚛️🔬. In each category, Dr. Gao’s research is marked by its innovation, addressing critical challenges in cancer treatment and drug delivery with a focus on precision medicine. His dedication to advancing medical science through transformative research continues to leave an indelible mark on the field. 🌟

🎓 Publications Top Note:

Research advances in peptide‒drug conjugates

Biomimetic multifunctional nanodrugs enable regulating abnormal tumor metabolism and amplifying PDT-induced immunotherapy for synergistically enhanced tumor ablation

Versatile flexible micelles integrating mucosal penetration and intestinal targeting for effectively oral delivery of paclitaxel

Development of Novel Paclitaxel-Loaded ZIF-8 Metal-Organic Framework Nanoparticles Modified with Peptide Dimers and an Evaluation of Its Inhibitory Effect against Prostate Cancer Cells

Triple Cross-linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF-κB and MAPK Signaling Pathways

Zhonggao Gao | Design of Novel | Best Researcher Award