Prof Dr.Qing Dai |Chemical | Best Researcher Award
Prof Dr. Qing Dai ,The University of Chicago, United States
Prof. Dr. Qing Dai is a distinguished professor at The University of Chicago, United States. He is renowned for his contributions to cutting-edge research in his field, with a particular focus on advanced technologies and innovation. Throughout his academic career, Dr. Dai has authored numerous influential publications and has been recognized for his expertise and leadership in research development. His work continues to have a significant impact in both academia and industry, fostering advancements in science and education. Prof. Dr. Qing Dai’s dedication to his field has made him a respected figure in the global academic community.
Summary:
Dr. Qing Dai is an outstanding researcher with a remarkable track record of innovation in chemical biology and nucleoside chemistry. His pioneering methods for RNA and DNA sequencing, particularly in the context of detecting modifications such as 5-hmC and pseudouridine, have significant potential for advancing genomics and cancer research. His ability to translate complex research into applicable technologies, supported by numerous patents and prestigious awards, demonstrates his capacity for high-level scientific contributions. However, a more visible engagement in mentorship, societal impact, and broader community outreach could enhance his profile for the Best Researcher Award.
Professional Profiles:
🎓 Education :
Dr. Qing Dai earned a Ph.D. in Organic Chemistry from the Institute of Elemento-Organic Chemistry at Nankai University, China, in June 1995. His doctoral research involved developing new methodologies for synthesizing alpha-amino phosphonic acids and phosphonopeptide derivatives. Prior to that, he received his Bachelor of Science in Chemistry from the Department of Chemistry at Central China Normal University, China, in June 1990.
🏢 Experience:
Dr. Dai has held multiple prominent positions at the University of Chicago. As a Research Professor (2018-present) in the Department of Chemistry, he has focused on developing ultrafast sequencing methods for RNA and DNA modifications, such as m5C and hm5C in RNA and 5mC/5hmC in DNA, along with profiling 5-hydroxymethylcytosine in cfDNA for biomarker studies. From 2011-2017, Dr. Dai served as a Research Associate Professor in the same department, where he innovated sequencing methods for 2′-OMe modification in mRNA and developed tools for genomic DNA modification studies, such as 5-hydroxymethylcytosine and 5-formylcytosine. Earlier, as a Research Assistant Professor (2005-2010) in the Department of Biochemistry & Molecular Biology, he synthesized nucleoside analogs for studies on RNA catalysis and RNA modification detection. His career at the University of Chicago began in 2002 as an Instructor at the Ben May Institute for Cancer Research, where he worked on synthesizing o-quinones for cancer research and developed new methodologies for regioselective arylation of nucleobases.
🛠️Skills:
Expertise in nucleoside and nucleotide chemistry, with experience synthesizing modified nucleosides for incorporation into RNA and DNA.,Development of high-throughput sequencing methods for detecting RNA and DNA modifications.,Synthesis and scaling up of drug candidates for medicinal chemistry applications.,Proficient in total synthesis of natural products with applications in anti-cancer research.,Skilled in process chemistry, including scaling up reactions for drug development.
🔬Awards:
Dr. Dai has received numerous accolades throughout his career. He is a co-principal investigator on the Centers of Excellence in Genomic Science (2021-2025) and was a recipient of the prestigious K01 Career Development Award (2012-2017). His earlier accomplishments include multiple grants, such as those from the National Key Laboratory and Nankai University. Additionally, Dr. Dai received the Excellent Ph.D. Dissertation Award from Nankai University in 1995, along with several scholarships during his academic journey.
Research Focus:
Dr. Dai’s research is highly interdisciplinary, spanning chemical biology, nucleic acid chemistry, and medicinal chemistry. He has pioneered the development of chemical tools for high-throughput sequencing of RNA and DNA modifications, particularly for detecting important epigenetic markers such as 5-hydroxymethylcytosine and pseudouridine. His expertise in nucleoside and nucleotide chemistry has been instrumental in advancing methodologies for synthesizing modified nucleosides for RNA and DNA studies. Dr. Dai has also significantly contributed to the field of drug discovery, including the design and synthesis of a novel drug candidate, DQ-29, which exhibits potent activity with reduced toxicity compared to existing compounds.
Conclusion:
Dr. Qing Dai is a strong candidate for the Best Researcher Award due to his groundbreaking research, particularly in sequencing technologies and RNA/DNA modification. His extensive research experience, success in obtaining competitive grants, and prolific patent work underscore his innovative contributions to science. However, to further strengthen his candidacy, expanding his public outreach, mentoring efforts, and demonstrating broader societal impact would be beneficial. Nonetheless, his exceptional technical expertise and research productivity make him a deserving contender for the award.
Publications :
Publication: IGF2BP3 promotes mRNA degradation through internal m7G modification
Authors: Liu, C., Dou, X., Zhao, Y., Xiao, Y., He, C.
Source: Nature Communications
Year: 2024
Publication: Pseudouridine Detection and Quantification Using Bisulfite Incorporation Hindered Ligation
Authors: Zhao, Y., Ma, X., Ye, C., Sun, H.-L., He, C.
Source: ACS Chemical Biology
Year: 2024
Publication: Quantification of tRNA m1A modification by templated-ligation qPCR
Authors: Zhang, W., Chen, H., Sobczyk, M., Dai, Q., Pan, T.
Source: RNA
Year: 2024
Publication: Chemical manipulation of m1A mediates its detection in human tRNA
Authors: Pajdzik, K., Lyu, R., Dou, X., Dai, Q., He, C.
Source: RNA
Year: 2024
Publication: A Quantitative Sequencing Method for 5-Formylcytosine in RNA
Authors: Lyu, R., Pajdzik, K., Sun, H.-L., He, C., Dai, Q.
Source: Israel Journal of Chemistry
Year: 2024
Publication: BID-seq for transcriptome-wide quantitative sequencing of mRNA pseudouridine at base resolution
Authors: Zhang, L.-S., Ye, C., Ju, C.-W., Dai, Q., He, C.
Source: Nature Protocols
Year: 2024
Publication: Base-Resolution Sequencing Methods for Whole-Transcriptome Quantification of mRNA Modifications
Authors: Zhang, L.-S., Dai, Q., He, C.
Source: Accounts of Chemical Research
Year: 2024
Publication: Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA
Authors: Dai, Q., Ye, C., Irkliyenko, I., Goel, A., He, C.
Source: Nature Biotechnology
Year: 2024
Publication: Dysregulation of the Epitranscriptomic Mark m1A in Ischemic Stroke
Authors: Chokkalla, A.K., Pajdzik, K., Dou, X., Arruri, V., Vemuganti, R.
Source: Translational Stroke Research
Year: 2023
Publication: Author Correction: m6A-SAC-seq for quantitative whole transcriptome m6A profiling
Authors: Ge, R., Ye, C., Peng, Y., Hu, L., He, C.
Source: Nature Protocols
Year: 2023