Dr . Aγγελικη Xagorari | BIOLOGY | Best Researcher Award

Dr . Aγγελικη Xagorari ,Thessaloniki Cord Blood Bank, Hematology Unit, G.Papanikolaou,Greece

Dr. Angeliki Xagorari is a distinguished researcher at the Thessaloniki Cord Blood Bank within the Hematology Unit of G. Papanikolaou Hospital in Greece. With a profound expertise in hematology and regenerative medicine, Dr. Xagorari has significantly contributed to the advancements in cord blood banking and stem cell research. Her work focuses on innovative treatments and therapies that leverage the unique properties of cord blood stem cells for hematological disorders and other medical conditions.

Education :

Research Experience:

1986-1987: Genetic study for the identification of a hybrid fish from parental species Leuciscus and Chalcarburnus, Lab of Genetics, Biology Department, Aristotelian University of ThessalonikiJan. 1990 – April 1990: Screening for the isolation of the TAG gene encoding for a neuroprotein, Lab of Molecular Biology, Institute of Molecular Biology and Biotechnology (IMBB), Heraklion, Crete, GreeceApril 1990 – July 1990: Screening for the isolation of the tRNA gene Saccharomyces cerevisiae, Lab of Yeast Genetics, IMBB, Heraklion, Crete, Greece,Sept. 1990 – Dec. 1990: Research on the subpopulation of T lymphocytes derived from different embryonal mice inbreds, Lab of Immunology, University of Crete, Heraklion, Crete, Greece,April 1991 – Dec. 1996: Ph.D. thesis: “Molecular characterization of the region 5q23-32: identification of two novel genes”, Lab of Molecular Biology, University of Crete and IMBB, Heraklion, Crete, Greece,Jan. 1997 – Mar. 1998: Postdoctoral position in Dr. Meisterernst’s Lab, Study on the human transcriptional cofactor NC2 and PC4 in C. elegans, Genzentrum, LMU, Munich, Germany,May 1998 – Jan. 1999: Postdoctoral position in Dr. Zorbas’ Lab, Study of the signal transduction mechanism of interferon α and β on regulatory factor IRF-1, Genzentrum, LMU, Munich, Germany,Jan. 1999 – Jan. 2002: Postdoctoral position, Study of the effects of tyrosine kinase inhibitors on signal transduction pathways in endotoxin-activated macrophages, Lab of Prof. Roussos in collaboration with Dr. Papapetropoulos, Medical School, University of Athens, Athens, Greece,Jan. 2002 – Dec. 2010: Gene Therapy Laboratory, Hematology Department/BMT Unit, G.Papanikolaou General Hospital

Teaching Experience:

Publications :

• Xagorari, A., & Anagnou, N. P. (1997). Simplified and rapid approach for the selection of cDNAs encoded by YACs. Trends in Genetics, 13(2), 82.
• Xagorari, A., Papapetropoulos, A., Mauromatis, A., Economou, M., Fotsis, T., & Roussos, C. (2001). Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and pro-inflammatory cytokine production in macrophages. Journal of Pharmacology and Experimental Therapeutics, 296(1), 181-187.
• Kosmidou, I., Xagorari, A., Roussos, C., & Papapetropoulos, A. (2001). Reactive oxygen species stimulate VEGF production from C2C12 skeletal myotubes through a PI3-K/Aκt pathway. American Journal of Physiology: Lung Cellular and Molecular Physiology, 280, L585-L592.
• Kotanidou, A., Xagorari, A., Bagli, E., Kitsanta, O., Fotsis, T., Papapetropoulos, A., & Roussos, C. (2002). Luteolin reduces LPS-induced lethal toxicity and expression of pro-inflammatory molecules in mice. American Journal of Respiratory and Critical Care Medicine, 165, 1-6.
• Kosmidou, I., Vassilakopoulos, T., Xagorari, A., Zakynthinos, S., Papapetropoulos, A., & Roussos, C. (2002). Production of interleukin-6 by skeletal myotubes: Role of reactive oxygen species. American Review of Respiratory Cell and Molecular Biology, 26, 1-7.
• Xagorari, A., Roussos, C., & Papapetropoulos, A. (2002). Inhibition of LPS-stimulated pathways in macrophages by the flavonoid luteolin. British Journal of Pharmacology, 136, 1058-1064.
• Yannaki, E., Athanasiou, E., Xagorari, A., Konstantinou, V., Batsis, I., Anagnostopoulos, A., & Fassas, A. (2005). G-CSF-primed hematopoietic stem cells accelerate recovery from acute and chronic carbon tetrachloride (CCl4)-induced liver injury. Experimental Hematology, 33, 108-119.
• Yannaki, E., Anagnostopoulos, A., Kapetanos, D., Xagorari, A., Iordanidis, F., Batsis, I., Kaloyannidis, P., Athanasiou, E., Dourvas, G., Kitis, G., & Fassas, A. (2006). Lasting amelioration in the clinical course of decompensated alcoholic cirrhosis with boost infusions of mobilized peripheral blood stem cells. Experimental Hematology, 34(11), 1583-1587.
• Xagorari, A., & Chlichlia, K. (2008). Toll-like receptors and viruses: induction of innate antiviral immune responses. Open Microbiology Journal, 2, 49-59.
• Tsingotjidou, A. S., Emmanouilides, C. E., Siotou, E., Poutahidis, T., Xagorari, A., Loukopoulos, P., Sotiropoulos, D., Bekiari, C., Doulberis, M., Givissis, P., Fassas, A., & Anagnostopoulos, A. (2009). Establishment of an animal model for Waldenström’s macroglobulinemia. Experimental Hematology, 37(4), 469-476.
• Yannaki, E., Papayannopoulou, T., Jonlin, E., Zervou, F., Karponi, G., Xagorari, A., Becker, P., Psatha, N., Batsis, I., Kaloyannidis, P., Tahynopoulou, V., Constantinou, V., Bouida, M., Kotta, K., Athanassiadou, A., Anagnostopoulos, A., Fassas, A., & Stamatoyannopoulos, G. (2012). Hematopoietic stem cell mobilization for gene therapy of adult patients with severe β-thalassemia: results of clinical trials using G-CSF or plerixafor in splenectomized and nonsplenectomized subjects. Molecular Therapy, 20(1), 230-238.
• Xagorari, A., Siotou, E., Yiangou, M., Tsolaki, E., Bougiouklis, D., Sakkas, L., Fassas, A., & Anagnostopoulos, A. (2013). Protective effect of mesenchymal stem cell-conditioned medium on hepatic cell apoptosis after acute liver injury. International Journal of Clinical and Experimental Pathology, 6(5), 831-840.